M U SCLE PHYS IOLOGY Muscle Research System The SI-MKB is the next research platform in the progression of studying living systems from the cellular level to whole organisms . It is the standard muscle research system, which can be configured to study skinned and intact muscle fibers, muscle strips and small whole muscles . The modular design of the SI-MKB allows it to be configured for turnkey solutions for specific applications . The system is built on a solid platform making precise mechanical and optical measurements easy . Like the Cell Tester and the SI-MT systems, the SI-MKB uses SI-KG optical force transducers and is constructed with corrosion-free materials (stainless steel, anodized aluminum or plastic) . Can be configured with specific components, like a linear motor or a stimulator, for measuring: l Responses to electrical stimulation, including tetany l Mechanical properties of contracting and relaxing muscle strips l Isotonic force and the effects of constant load l Twitch amplitude and kinetics, like contraction and relaxation times and velocities l Slack, quick stretch-release, constant velocity and eccentric contraction tests l Afterloaded contractions from cardiac muscles l Vibrational studies that simulate unloaded muscle shortening l Quick temperature-change effects on skinned and intact muscle fibers Can be equipped with components, like a laser diode or a photometer, for measuring: l Sarcomere length/spacing by laser diffraction at the same time muscle force is measured l Intracellular calcium concentration/distribution in intact muscle fibers as muscle force is measured l ATPase activity in skinned muscle fibers as muscle force is measured SI-MKB Supplied with a Labtrax 8/16 data acquisition system and MDAC software for: l Recording signals from the force transducer and the motor position monitor, through four analog inputs l Controlling the stimulator, or an external stimulus isolator, through an analog output l Controlling the position of the linear motor through a second analog output l Controlling other devices through two digital outputs SOME SYSTEMS AVAILABLE FOR INTACT MUSCLE FIBERS INCLUDE: SI-MKBM-OXY System with a 5cm heated cuvette and a linear motor SI-MKB-OXY System with a 5cm heated cuvette and a digital micrometer Systems include: Base plate; force transducer and stand, digital micrometer or linear motor (optional), micrometer or motor stand, cuvette and table, oxygenation system, evacuation system, signal conditioning system with transducer amplifier and temperature control module, anti-oscillation module and linear motor amplifier (if applicable), Lab-Trax 8/16 data acquisition system with MDAC software for recording force and position signals and for controlling stimulation and the movement of the linear motor . Tissue Mounts Tweezer Basket Pointed Hook Blunt Hook Spring Clip Screw Clip Tendon Hook l Different styles (tweezers, baskets, hooks, clips) for mounting different types of tissue to the transducer, and to the linear motor or micrometer l Most styles available in sizes to fit each model of KG transducer l Sold in a variety of sets, each set contains two tissue mounts that are appropriate for the type of tissue being tested 4 World Precision Instruments UK: Tel: +44 (0)1462 424700 • wpiuk@wpi-europe.com www.wpiinc.com Germany: Tel: +49 (0)30-6188845 • wpide@wpi-europe.com US: Tel: 941-371-1003 • sales@wpiinc.com