Refer to www.wpiinc.com/myocyte or request the new Muscle Physiology catalog for details on the complete line of muscle physiology equipment and accessories. Perfused System Features l Constant flow and constant pressure modes l Can be equipped to measure perfusion pressure, arterial flow and buffer temperature l Perfusion pressure up to 120mmHg l Maintain buffer temperature with waterjacketed reservoir l Lubricant-free Teflon taps l External circulating water bath for the buffer reservoir l Internal heater/controller for the organ bath l Supplementary thermostat in the organ bath l Constant oxygenation of the buffer Neely M U SCLE PHYS IOLOGY Isolated working heart system The SI-LAnGWH isolated working heart system was developed for in vitro measurements of the mechanical activity and work performed by hearts from small animals according to the methods devised by J . R . Neely, et al. This system is designed with a combination of features from both the classic Langendorff (retrograde perfusion) and Neely (working heart) systems . Features l For use on small mammalian hearts (mouse, rat, guinea pig, hamster and rabbit) l Working heart (Neely) and retrograde perfusion (Langendorff) options in the same device l Control of the left ventricular diastolic pressure (LVDP), coronary flow and cardiac output by variation of the left atrial filling pressure and the hydrostatic pressure in the aorta l Measurement of the heart rate, atrial and ventricular pressure and cardiac output l Ports for drug administration l Pacing of the heart is possible l Special MAP sensor available l Tissue easily removed for biochemical investigations Perfusion Chamber Each perfusion chamber has an organ holder, water bath, heater, vaporizer, perfusion inlet and outlet, thermosensor port, supplementary thermostat, mesh organ fastener, acrylic lid, and blood vessels and ureter ports . Optional Accessories The following accessories may be added to complete your system: Temperature probe • Flow sensor and monitor • Liver/gut perfusion chamber • Data acquisition system ISOLATED PERFUSED ORGAN SYSTEM SI-IPOKIDNEY Isolated Perfused Organ (Kidney) System Included: Heated tissue bath • Table with base plate • Console • Perfusion buffer column • Glass overflow tube • Pressure sensor holder • Oxygenation bubbler set • Oxygenation pressure equalizer set • Silicone tubing set, cables, accessories • Peristaltic pumps (2) • Circulating water bath • Pressure transducer with cable • Pressure transducer amplifier The Neely system is designed as a perfusion system for isolated, small mammalian hearts. Some special features of this system include the stainless steel sink, the small reeling pump and specially designed twoway Teflon taps. NEELY SYSTEM SI-LANGWH Langendorf Neely Perfused Working Heart System System includes: Table with base plate, sink, shelf; console; buffer column; overflow tube; lung column; elastic chambers (2); tap valve; heart suspension cannula; heart chamber; oxygenation system; pressure transducers with cables (2); 2-channel pressure sensor amplifier; catheter balloons; Peristar-Pro high output peristaltic pumps (2); circulating water bath; tubing, cables, and accessories. OPTIONAL COMPONENTS SI-SEN12AM4E-U Manipulator with Removable Head (Unipolar) SI-SEN12AM4E-B Manipulator with Removable Head (Bipolar) SI-SEN07RTH2 Buffer Temperature Sensor SI-SEN13MAP Monopolar Action Potential Sensor World Precision Instruments www.wpiinc.com Germany: Tel: +49 (0)30-6188845 • wpide@wpi-europe.com US: Tel: 941-371-1003 • sales@wpiinc.com OPTIONAL COMPONENTS SI-LF-05-01-IPO Alternate Tissue Bath for Liver or Mesenteric Bed UK: Tel: +44 (0)1462 424700 • wpiuk@wpi-europe.com 9