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39
l
Neurone
·
Vol 17
·
N°9
·
2012
dans la présente revue, la MLT est plus
qu'une efférence des NSC. Du fait de la
présence de récepteurs melatoniner-
giques dans les SCN, la MLT exogène a
des propriétés chronobiotiques. Les ago-
nistes et antagonistes spécifiques aux di-
vers récepteurs de la MLT sont donc des
outils pharmacologiques utiles aux inno-
vations thérapeutiques dans ce domaine
particulier.
Références
1.
Challet E, Pevet P. Interactions between photic and
nophotic stimuli to synchronize the mammalian
circadian clock. Frontiers in Bioscience 2003;8:246-57.
2.
Challet E., Mendoza J, Dardente H, et al. Neurogenetics
of food anticipation. Europ. J. Neurosc 2009;30:1676-
87.
3.
Dardente H, Cermakian N. How many pieces to build a
circadian clock? Med Sci (Paris) 2005;21:66-72.
4.
Schibler U, Ripperger J, Brown SA. Peripheral circadian
oscillators in mammals: time and food. J Biol Rhythms
2003;18:250-60.
5.
Mendoza J, Pevet P, Felder-Schmittbuhl MP, et al. The
cerebellum harbors a circadian oscillator involved in
food anticipation J. Neuroscience 2010;30:1894-1904.
6.
Pevet P, Challet E. Melatonin: Both master clock output
and internal time-giver in the circadian clocks network.
J Physiol Paris 2011 (in press).
7.
Yoo SH, Yamazaki S, Lowrey PL, et al. Period2 luciferase
real-time reporting of circadian dynamics reveals
persistent circadian oscillations in mouse peripheral
tissues. Proc Natl Acad Sci USA 2004;101:5339-46.
8.
Challet E. Interactions between light, mealtime and
calorie restriction to control daily timing in mammals. J
Comp Physiol B 2010;180:631-44.
9.
Schibler U. Peripheral phase coordination in the
mammalian circadian timing system. J Biol Rhythms
2009;24:3-15.
10.
Silver R, LeSauter J, Tresco PA, et al. A diffusible
coupling signal from the transplanted suprachiasmatic
nucleus controlling circadian locomotor rhythms.
Nature 1996;382:810-13.
11.
Cheng MY, Bullock CM, Li C, et al. Prokineticin 2
transmits the behavioural circadian rhythm of the
suprachiasmatic nucleus. Nature 2002;417:405-10.
12.
Buijs RM, Kalsbeek A. Hypothalamic integration of
central and peripheral clocks. Nat Rev Neurosci
2001;7:521-6.
13.
Buijs RM. The anatomical basis for the expression of
circadian rhythms: the efferent projections of the
suprachiasmatic nucleus. Prog Brain Res 1996;111:229-
40.
14.
Kalsbeek A, Buijs RM. Output pathways of the
mammalian suprachiasmatic nucleus: coding circadian
time by transmitter selection and specific targeting. Cell
Tissue Res 2002;309:109-18.
15.
Kalsbeek A, Palm IF, La Fleur SE, et al. SCN outputs and
the hypothalamic balance of life. J Biol Rhythms
2006;21:458-69.
16.
Kalsbeek A, Yi CX, Cailotto C, et al. Mammalian clock
output mechanisms. Essays Biochem 2011;49:137-51.
17.
Dickmeis T. Glucocorticoids and the circadian clock. J
Endocrinol 2009;200:3-22.
18.
Buijs RM, Wortel J, Van Heerikhuize JJ, et al. Novel
environment induced inhibition of corticosterone
secretion: physiological evidence for a suprachiasmatic
nucleus mediated neuronal hypothalamo-adrenal cortex
pathway. Brain Res 1997;758:229-36.
19.
Sage D, Maurel D, Bosler O. Corticosterone-dependent
driving influence of the suprachiasmatic nucleus on
adrenal sensitivity to AC TH. Am J Physiol Endocrinol
Metab 2002;282:E458-465.
20.
Malek Z, Sage D, Pevet P, et al. Daily rhythm of
tryptophan hydroxylase-2-mRNA: within raphe neurons
is induced by corticoid daily surge and modulated by
enhanced
locomoteor
activity.
Endocrinology
2007;148:5165-72.
21.
Nexon L, Sage D, Pevet P, et al. Glucocorticoides
mediated nycthemeral and photoperiodic regulation of
tph2 expression. Europ J Neurosc 2011;33:1308-17.
22.
Arendt J. Melatonin: characteristics, concerns, and
prospects. J Biol Rhythms 2005;20:291-303.
23.
Teclemariam-Mesbah R, Ter Horst GJ, Postema F, et al.
Anatomical demonstration of the suprachiasmatic nucleus-
pineal pathway. J Comp Neurol 1999;406:171-82.
24.
Perreau-Lenz S, Kalsbeek A, Garidou ML, et al.
Suprachiasmatic control of melatonin synthesis in rats:
inhibitory and stimulatory mechanisms. Eur J Neurosci
2003;17:221-8.
25.
Perreau-Lenz S, Kalsbeek A, van Der Vliet V, et al. In vivo
evidence for a controlled offset of melatonin synthesis at
dawn by the suprachiasmatic nucleus in the rat.
Neuroscience 2005;130:797-803.
26.
Pevet P. Melatonin: from seasonal to circadian signal. J
Neuroendocrinol 2003;15:1-5.
27.
Masson-Pevet M, George D, Kalsbeek A, et al. An
attempt to correlate brain areas containing melatonin
binding sites with rhythmic functions: A study in five
hibernator species. Cell Tiss Res 1994;278:97-106.
28.
Pevet P. The melatonin. Dialogues in clinical
Neurosciences 2002;4:57-72.
29.
Messager S, Garabette ML, Hastings MH, et al. Tissue-
specific abolition of Per1 expression in the pars tuberalis
by pinealectomy in the Syrian hamster. Neuroreport
2001;12:579-82.
30.
Dardente H, Menet JS, Poirel VJ, et al. Melatonin
induces Cry1 expression in the pars tuberalis of the rat.
Mol Brain Res 2003;114:91-182.
31.
Torres-Farfan C, Mendez N, Abarzua-Catalan L, et al. A
circadian clock entrained by melatonin is ticking in the
rat fetal adrenal. Endocrinology 2011;152:1891-900.
32.
Arendt J, Skene DJ. Melatonin as a chronobiotic. Sleep
Med Rev 2005;9:25-39.
33.
Pevet P, Bothorel B, Slotten H, et al. The chronobiotic
effect of melatonin. Cell Tiss Res 2002;309:183-191.
34.
Pitrosky B, Kirsch R, Malan A, et al. Organization of rat
circadian rhythms during daily infusion of melatonin or
S20098, a melatonin agonist. Am J Physiol
1999;277:R8126-R828.
35.
Hack LM, Lockley SW, Arendt J, et al. The effects of low-
dose 0.5-mg melatonin on the free-running circadian
rhythms of blind subjects. J Biol Rhythms 2003;18:420-9.
36.
Claustrat B, Brun J, David M, et al. Melatonin and jet lag:
confirmatory result using a simplified protocol. Biol
Psychiatry 1992;32:705-6.
37.
Van Someren EJ. Circadian and sleep disturbances in the
elderly. Exp Gerontol 2000;35:1229-37.
38.
Touitou Y. Human aging and melatonin. Clinical
relevance. Exp Gerontol 2001;36:1083-100.
Actualités de la
sclérose tubéreuse
de Bourneville
Cet article propose une
mise à jour des connais-
sances concernant cette affection rare, d'ori-
gine génétique et d'expression surtout neuro-
logique et psychiatrique. Des avancées géné-
tiques et biochimiques permettent d'envisa-
ger des progrès manifestes dans la prise en
charge. Il est donc important d'éviter le
«sous-diagnostic» et le diagnostic tardif.
A découvrir
sur neurone.be
Une «clause de non-concurrence»
pour les médecins?
Notre législation du travail inclut le principe
de la «clause de non-concurrence». En vertu
de cette disposition, un collaborateur qui quitte son entreprise ne
peut exercer aucune activité similaire. Autrement dit, ce collabo-
rateur ne peut ni lancer lui-même une société, ni exercer dans
une entreprise concurrente de son ex-employeur une fonction
risquant de porter préjudice à ce dernier. L'ex-collabora-
teur en question pourrait notam-
ment utiliser à des fins
personnelles ou à
l'avantage d'une en-
treprise concurrente
les connaissances
acquises dans la société
de son ex-employeur.