Percentiel
|
Vol 18
|
Nr 4
|
2013
15
figuur 2: Geen verschil in totale overleving na 8 jaar tussen
transplantatie van HLa-compatibel beenmerg en transplantatie van
stamcellen uit navelstrengbloed.
100
80
60
40
20
0
100
80
60
40
20
0
12
24
36
48
60
72
84
96
108
Months
P
r
obabilit
y (%)
Matched BM vs. UCB: HR = 0.83, p = 0.41
Mismatched BM vs. UCB: HR = 1.66, p = 0.03
Mismatched BM vs. matched BM: HR = 2.00, p < 0.01
Mismatched BM (68%)
Matched BM (81%)
Cord blood (78%)
Any T cell
CD3
TCR
Blina-
tumomab
CD19
Act independently of speci city
of T Cell Receptor (TCR)
Allow T cells recognition of
Tumor-Associated
surface Antigen (TAA)
Do not require
MHC Class I
and/or peptide antigen
Tumor cell
figuur 4: chimere cellen werken via onafhankelijke herkenning van histocompatibiliteitsantigenen en incorporeren de costimuleringssignalen van
het cytotoxische effect.
Antigen-
presenting cell
Antigen-
presenting cell
MHC
Peptide
TCR
CD80
CD28
T cell
Signal 2
Signal 1
T cell receptor signaling
A
CD80
CD28
T cell
Signal 2
Signal 1
1
st
generation CAR signaling
B
Tumor cell
CAR
Linker
TM
scFv
Antigen
T cell
Signal 1 and 2
2
nd
generation CAR signaling
C
Tumor cell
scFv
Antigen
Co-stim 1
T cell
Signal 1 and 2
3
rd
generation CAR signaling
D
Tumor cell
scFv
Antigen
Co-stim 1
Co-stim 2
figuur 3: Werkingsmechanisme van Bite
®
-antistoffen