clarify the role and function
of B lymphocytes in health
and disease. His focus is on
human B1 cells, a unique
B lymphocyte subset that
produces "natural" antibody
and regulates T-cell activity.
Human B1 cells may be
important in understanding
and treating autoimmune
diseases and degenerative
diseases of aging.
basic and clinical research
to conduct a number of
experimental drug trials
for patients suffering from
chronic lymphocytic leukemia
(CLL), a cancer that resides
in the blood, bone marrow
and lymphoid tissues. His
studies have impacted CLL
patient prognosis and care.
glioblastoma and
medulloblastoma, the most
common types of brain
tumors in adults and children.
She is working on the
development of an inhibitor
that could provide novel
treatments for these types
of tumors.
conducting clinical islet
cell transplant for patients
suffering from chronic
pancreatitis and type 1
diabetes, and performing
immunotherapy for
pancreatic cancer. His
research focuses on mitigating
transplant rejection,
preservation of donor organs
and development of stem
cell therapies to treat life-
threatening diseases.
research is concerned with
the control of monocyte and
dendritic cell development
in normal and abnormal
physiology as well as
developing new therapeutic
agents for autoimmune
diseases. Current work
focuses on disrupted cytokine
and immunoreceptor
networks affecting monocyte/
dendritic cell activity,
particularly in rheumatoid
arthritis and lupus.
episode schizophrenia
research network, which
includes sites across the
country and in Canada,
study pharmacotherapy for
schizophrenia. The network
is currently conducting
the RAISE trial, which
assesses psychosocial and
pharmacological treatments
for schizophrenia.
cardiac metabolism research
and examines the role of
the ubiquitin proteasome
system in cellular function
and malfunction. He conducts
ongoing studies that examine
altered function of the
ubiquitin proteasome system
in several diseases.
on obesity and diabetes.
Projects include devising
earlier ways to diagnose and
treat diabetes, understanding
how excess body weight
brings out diabetes,
and uncovering how the
microbiome, the microbes
in the intestine of the host,
influence the host's food
intake and body weight.