![]() researched and worked in the area of academic general internal medicine with a focus on providing high- quality health care in urban communities. Recent areas of focus include the validation of clinical prediction rules, as well as the prevalence, risk factors and treatment of hepatitis C. methods for measuring brain structure and function to advance understanding of human brain function and the treatment of epilepsy. The lab works to improve the diagnosis of epilepsy patients, and better understand the root causes of epilepsy, and the physiological basis of brain structure, function and cognition. whose primary interests are in lupus, rheumatoid arthritis, scleroderma and vasculitis. She is a co-director of the Clinical Trials Unit and conducts studies to better understand and develop treatments for autoimmune disease. focused on the molecular basis of hematopoietic stem cell disorders, collectively referred to as the inherited bone marrow failure syndromes. His current research is aimed at understanding the molecular pathophysiology of Diamond Blackfan anemia and Shwachman-Diamond syndrome. His lab also researches erythropoiesis and sickle cell anemia. on inflammation in both pregnant and non-pregnant populations and identifying ways to reduce and prevent dysfunctional inflammation. Much of her work centers on endothelial cells, which facilitate the rapid transport of blood and immune cells throughout the body, particularly to sites of infection and inflammation. on identifying the biological underpinnings of schizophrenia and determining how antipsychotic drugs work to quell the symptoms of the disease. His group assesses genes and neural circuits associated with increased risk for schizophrenia with the goal of developing more effective treatments. on molecular mechanisms of septic shock, and septic multiple organ injury. Using modern molecular biology techniques, his goal is to discover the key molecules that can be new targets for developing new therapies. focuses on the molecular basis of neuronal degeneration in Alzheimer's disease and other dementias. His laboratory studies the early biochemical changes leading to the formation of two classic lesions of the Alzheimer's disease brain: the senile plaques and the neurofibrillary tangles. |