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RESEARCH DIRECTORY
Dr. McGinn has taught,
researched and worked in
the area of academic general
internal medicine with a
focus on providing high-
quality health care in urban
communities. Recent areas of
focus include the validation
of clinical prediction rules,
as well as the prevalence,
risk factors and treatment of
hepatitis C.
Dr. Mehta's lab uses multiple
methods for measuring brain
structure and function to
advance understanding of
human brain function and
the treatment of epilepsy.
The lab works to improve the
diagnosis of epilepsy patients,
and better understand the
root causes of epilepsy, and
the physiological basis of
brain structure, function and
cognition.
Dr. Mackay is a rheumatologist
whose primary interests
are in lupus, rheumatoid
arthritis, scleroderma and
vasculitis. She is a co-director
of the Clinical Trials Unit
and conducts studies to
better understand and
develop treatments for
autoimmune disease.
Dr. Liu's research career has
focused on the molecular
basis of hematopoietic
stem cell disorders,
collectively referred to as
the inherited bone marrow
failure syndromes. His
current research is aimed
at understanding the
molecular pathophysiology
of Diamond Blackfan anemia
and Shwachman-Diamond
syndrome. His lab also
researches erythropoiesis and
sickle cell anemia.
Dr. Metz's research focuses
on inflammation in both
pregnant and non-pregnant
populations and identifying
ways to reduce and prevent
dysfunctional inflammation.
Much of her work centers
on endothelial cells, which
facilitate the rapid transport
of blood and immune
cells throughout the body,
particularly to sites of
infection and inflammation.
Dr. Malhotra works
on identifying the
biological underpinnings
of schizophrenia and
determining how
antipsychotic drugs work to
quell the symptoms of the
disease. His group assesses
genes and neural circuits
associated with increased
risk for schizophrenia with
the goal of developing more
effective treatments.
Dr. Liu's research focus is
on molecular mechanisms
of septic shock, and septic
multiple organ injury. Using
modern molecular biology
techniques, his goal is to
discover the key molecules
that can be new targets for
developing new therapies.
Dr. Marambaud's research
focuses on the molecular
basis of neuronal
degeneration in Alzheimer's
disease and other dementias.
His laboratory studies the
early biochemical changes
leading to the formation of
two classic lesions of the
Alzheimer's disease brain:
the senile plaques and the
neurofibrillary tangles.
THOMAS MCGINN, MD
Patient-Oriented Research
ASHESH MEHTA, MD, PHD
Neuroscience
MEGGAN MACKAY, MD
Autoimmune &
Musculoskeletal Disease
JOHNSON LIU, MD
Oncology & Cell Biology
CHRISTINE METZ, PHD
Immunology & Inflammation
ANIL MALHOTRA, MD
Psychiatric Neuroscience
SHU FANG LIU, MD, PHD
Heart & Lung Research
PHILIPPE MARAMBAUD, PHD
Alzheimer's Disease &
Memory Disorders
28
2015 ANNUAL REPORT