on the mechanisms of the
antibody-mediated neuronal
abnormalities leading to brain
pathology and to hormonal
serum alterations in lupus.
Projects include the function
of the blood-brain barrier
in the antibody-mediated
pathology of the adult brain
and of the maternal antibody-
mediated abnormalities in the
developing brain.
focus is to discover and
validate new biomarkers for
early detection, prediction of
disease course and outcome
and treatment response in
cancer, particularly breast and
ovarian cancers.
is to identify regulatory
mechanisms of inflammatory
function of dendritic cells
under both homeostatic and
inflammatory conditions. This
is with the goal to understand
the molecular mechanisms
that inhibit the development
of autoimmune diseases,
particularly in lupus and
inflammatory bowel diseases.
biomarkers, especially novel
genetic technologies, to better
understand the causes and
treatment of schizophrenia.
He develops and implements
strategies for identifying
relationships between genetic
variation and psychiatric
disease, and examines the
role that schizophrenia risk
genes play in brain structure,
function and development.
focuses on elucidating
the biology of behavioral
disturbances in Alzheimer's
disease and the development
of novel treatments. Recent
work has focused on the
endocannabinoid system in
Alzheimer's disease and the
contribution of abnormal
tau protein deposition to the
development of psychotic
symptoms.
and assists investigators
in data analysis, research
question formulation, study
design, data management,
storage and retrieval, as well
as publication preparation
and patient safety and data
quality monitoring.
on monitoring and treating
the injured brain. Projects
include developing the
next generation brain
multimodality monitoring
devices using BioMEMS
technology, and investigating
trigeminal nerve stimulation
as a novel therapeutic
approach to traumatic brain
injury by the activation of
endogenous neuroprotective
mechanisms.
research is the elucidation
of the genetics and
pathophysiology of Diamond-
Blackfan anemia (DBA),
a disorder of the bone
marrow. He is working with
numerous collaborators to
develop genotype-phenotype
correlations, resulting in the
discovery of a number of
DBA genotypes.